Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9Y6N7
UPID:
ROBO1_HUMAN
Alternative names:
Deleted in U twenty twenty; H-Robo-1
Alternative UPACC:
Q9Y6N7; B2RXI1; D3DU36; E9PD49; Q1RMC7; Q7Z300; Q9BUS7
Background:
Roundabout homolog 1, also known as Deleted in U twenty twenty and H-Robo-1, plays a pivotal role in neuronal development, guiding axonal navigation and cellular migration. It functions as a receptor for SLIT1 and SLIT2, mediating responses to molecular guidance cues. Its interaction with MYO9B regulates cell migration by modulating RHOA GTPase activity, essential for lung development and axon growth.
Therapeutic significance:
Roundabout homolog 1 is implicated in Neurooculorenal syndrome, Nystagmus 8, and Pituitary hormone deficiency, highlighting its therapeutic potential. Understanding the role of Roundabout homolog 1 could open doors to potential therapeutic strategies for these conditions, emphasizing the importance of targeted research in uncovering novel treatments.